Twenty-four-hour ambulatory blood pressure monitoring efficacy of perindopril/indapamide first-line combination in hypertensive patients: the REASON study
Identifieur interne : 00A837 ( Main/Exploration ); précédent : 00A836; suivant : 00A838Twenty-four-hour ambulatory blood pressure monitoring efficacy of perindopril/indapamide first-line combination in hypertensive patients: the REASON study
Auteurs : Jean-Michel Mallion [France] ; Bernard Chamontin [France] ; Roland Asmar [France] ; Peter Wilhelmus De Leeuw [Pays-Bas] ; Eoin O'Brien [Irlande (pays)] ; Daniel Duprez [Belgique, États-Unis] ; Michael F. O'Rourke [Australie] ; Karl-Heinz Rahn [Allemagne] ; Ramon Romero [Espagne] ; Edouard Battegay [Suisse] ; Gerhart Hitzenberger [Autriche] ; Michel E. Safar [France]Source :
- American Journal of Hypertension [ 0895-7061 ] ; 2004-03.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- ACE inhibitor, Ambulatory, Antihypertensive drug treatment, Cardiovascular disease, Enzyme inhibitor, Human, Hypertension, Indapamide, Monitoring, Peptidyl-dipeptidase A, Perindopril, ambulatory blood pressure measurement, blood pressure variability, perindopril/indapamide combination, smoothness index, trough/peak ratio.
Abstract
Background: Circadian blood pressure (BP) measurements provide more information on hypertensive complications than office BP measurements. The purpose of this study was to analyze the efficacy of the first-line combination of perindopril 2 mg plus indapamide 0.625 mg versus atenolol 50 mg on BP parameters and variability over 24 h in patients with hypertension. Methods: A double-blind, randomized, controlled, 12-month study comparing perindopril/indapamide and atenolol was performed in 201 patients (age 55.0 years) with uncomplicated sustained essential hypertension. Ambulatory BP measurements (ABPM) were done every 15 min over 24 h. Results: After 1 year of treatment, the decrease in systolic BP was significantly greater for perindopril/indapamide than for atenolol during the entire 24-h period (-13.8 ν −9.2 mm Hg), the daytime and the nighttime periods (P < .01). Diastolic blood pressure (DBP) variations were comparable for the two groups (−7.2 ν −8.3 mm Hg, NS). Pulse pressure (PP) reduction was also significantly greater for perindopril/indapamide than for atenolol (for the whole 24 h, −6.6 ν −0.9 mm Hg, P < .001). The through to peak (T/P) BP ratio and the smoothness index were comparable in the two groups for DBP. For systolic blood pressure (SBP), higher values of the T/P ratio (0.80 ν 0.59) and the smoothness index (1.45 ν 0.98; P < .02) were achieved for the perindopril/indapamide combination than for atenolol. Conclusions: The perindopril/indapamide first-line combination decreased SBP and PP more effectively than atenolol. Moreover, the BP control effect was smooth and consistent throughout the 24-h dosing interval and BP reduction variability was lower than the one induced by atenolol.
Url:
DOI: 10.1016/j.amjhyper.2003.11.001
Affiliations:
- Allemagne, Australie, Autriche, Belgique, Espagne, France, Irlande (pays), Pays-Bas, Suisse, États-Unis
- District de Münster, Midi-Pyrénées, Minnesota, Occitanie (région administrative), Rhénanie-du-Nord-Westphalie, Vienne (Autriche), Île-de-France
- Münster, Paris, Toulouse, Vienne (Autriche)
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O'Rourke</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Saint Vincent's Hospital, Darlinghurst</wicri:regionArea><wicri:noRegion>Darlinghurst</wicri:noRegion></affiliation></author><author><name sortKey="Rahn, Karl Heinz" sort="Rahn, Karl Heinz" uniqKey="Rahn K" first="Karl-Heinz" last="Rahn">Karl-Heinz Rahn</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Poliklinik, University of Münster, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Romero, Ramon" sort="Romero, Ramon" uniqKey="Romero R" first="Ramon" last="Romero">Ramon Romero</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Germans Trias y Pujol, Badalona</wicri:regionArea><wicri:noRegion>Badalona</wicri:noRegion></affiliation></author><author><name sortKey="Battegay, Edouard" sort="Battegay, Edouard" uniqKey="Battegay E" first="Edouard" last="Battegay">Edouard Battegay</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Medizinische Universitäts Poliklinik, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Hitzenberger, Gerhart" sort="Hitzenberger, Gerhart" uniqKey="Hitzenberger G" first="Gerhart" last="Hitzenberger">Gerhart Hitzenberger</name><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Institut für Hypertoniker, Wien</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Safar, Michel E" sort="Safar, Michel E" uniqKey="Safar M" first="Michel E." last="Safar">Michel E. Safar</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Broussais, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">American Journal of Hypertension</title><title level="j" type="abbrev">AJH</title><idno type="ISSN">0895-7061</idno><idno type="eISSN">1941-7225</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2004-03">2004-03</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="245">245</biblScope><biblScope unit="page" to="251">251</biblScope></imprint><idno type="ISSN">0895-7061</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0895-7061</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ACE inhibitor</term><term>Ambulatory</term><term>Antihypertensive drug treatment</term><term>Cardiovascular disease</term><term>Enzyme inhibitor</term><term>Human</term><term>Hypertension</term><term>Indapamide</term><term>Monitoring</term><term>Peptidyl-dipeptidase A</term><term>Perindopril</term><term>ambulatory blood pressure measurement</term><term>blood pressure variability</term><term>perindopril/indapamide combination</term><term>smoothness index</term><term>trough/peak ratio</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Ambulatoire</term><term>Appareil circulatoire pathologie</term><term>Homme</term><term>Hypertension artérielle</term><term>Indapamide</term><term>Inhibiteur angiotensin converting enzyme</term><term>Inhibiteur enzyme</term><term>Monitorage</term><term>Peptidyl-dipeptidase A</term><term>Périndopril</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Circadian blood pressure (BP) measurements provide more information on hypertensive complications than office BP measurements. The purpose of this study was to analyze the efficacy of the first-line combination of perindopril 2 mg plus indapamide 0.625 mg versus atenolol 50 mg on BP parameters and variability over 24 h in patients with hypertension. Methods: A double-blind, randomized, controlled, 12-month study comparing perindopril/indapamide and atenolol was performed in 201 patients (age 55.0 years) with uncomplicated sustained essential hypertension. Ambulatory BP measurements (ABPM) were done every 15 min over 24 h. Results: After 1 year of treatment, the decrease in systolic BP was significantly greater for perindopril/indapamide than for atenolol during the entire 24-h period (-13.8 ν −9.2 mm Hg), the daytime and the nighttime periods (P < .01). Diastolic blood pressure (DBP) variations were comparable for the two groups (−7.2 ν −8.3 mm Hg, NS). Pulse pressure (PP) reduction was also significantly greater for perindopril/indapamide than for atenolol (for the whole 24 h, −6.6 ν −0.9 mm Hg, P < .001). The through to peak (T/P) BP ratio and the smoothness index were comparable in the two groups for DBP. For systolic blood pressure (SBP), higher values of the T/P ratio (0.80 ν 0.59) and the smoothness index (1.45 ν 0.98; P < .02) were achieved for the perindopril/indapamide combination than for atenolol. Conclusions: The perindopril/indapamide first-line combination decreased SBP and PP more effectively than atenolol. Moreover, the BP control effect was smooth and consistent throughout the 24-h dosing interval and BP reduction variability was lower than the one induced by atenolol.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Espagne</li><li>France</li><li>Irlande (pays)</li><li>Pays-Bas</li><li>Suisse</li><li>États-Unis</li></country><region><li>District de Münster</li><li>Midi-Pyrénées</li><li>Minnesota</li><li>Occitanie (région administrative)</li><li>Rhénanie-du-Nord-Westphalie</li><li>Vienne (Autriche)</li><li>Île-de-France</li></region><settlement><li>Münster</li><li>Paris</li><li>Toulouse</li><li>Vienne (Autriche)</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Mallion, Jean Michel" sort="Mallion, Jean Michel" uniqKey="Mallion J" first="Jean-Michel" last="Mallion">Jean-Michel Mallion</name></noRegion><name sortKey="Asmar, Roland" sort="Asmar, Roland" uniqKey="Asmar R" first="Roland" last="Asmar">Roland Asmar</name><name sortKey="Chamontin, Bernard" sort="Chamontin, Bernard" uniqKey="Chamontin B" first="Bernard" last="Chamontin">Bernard Chamontin</name><name sortKey="Mallion, Jean Michel" sort="Mallion, Jean Michel" uniqKey="Mallion J" first="Jean-Michel" last="Mallion">Jean-Michel Mallion</name><name sortKey="Mallion, Jean Michel" sort="Mallion, Jean Michel" uniqKey="Mallion J" first="Jean-Michel" last="Mallion">Jean-Michel Mallion</name><name sortKey="Safar, Michel E" sort="Safar, Michel E" uniqKey="Safar M" first="Michel E." last="Safar">Michel E. Safar</name></country><country name="Pays-Bas"><noRegion><name sortKey="Leeuw, Peter Wilhelmus De" sort="Leeuw, Peter Wilhelmus De" uniqKey="Leeuw P" first="Peter Wilhelmus De" last="Leeuw">Peter Wilhelmus De Leeuw</name></noRegion></country><country name="Irlande (pays)"><noRegion><name sortKey="O Brien, Eoin" sort="O Brien, Eoin" uniqKey="O Brien E" first="Eoin" last="O'Brien">Eoin O'Brien</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Duprez, Daniel" sort="Duprez, Daniel" uniqKey="Duprez D" first="Daniel" last="Duprez">Daniel Duprez</name></noRegion></country><country name="États-Unis"><region name="Minnesota"><name sortKey="Duprez, Daniel" sort="Duprez, Daniel" uniqKey="Duprez D" first="Daniel" last="Duprez">Daniel Duprez</name></region></country><country name="Australie"><noRegion><name sortKey="O Rourke, Michael F" sort="O Rourke, Michael F" uniqKey="O Rourke M" first="Michael F." last="O'Rourke">Michael F. O'Rourke</name></noRegion></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Rahn, Karl Heinz" sort="Rahn, Karl Heinz" uniqKey="Rahn K" first="Karl-Heinz" last="Rahn">Karl-Heinz Rahn</name></region></country><country name="Espagne"><noRegion><name sortKey="Romero, Ramon" sort="Romero, Ramon" uniqKey="Romero R" first="Ramon" last="Romero">Ramon Romero</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Battegay, Edouard" sort="Battegay, Edouard" uniqKey="Battegay E" first="Edouard" last="Battegay">Edouard Battegay</name></noRegion></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Hitzenberger, Gerhart" sort="Hitzenberger, Gerhart" uniqKey="Hitzenberger G" first="Gerhart" last="Hitzenberger">Gerhart Hitzenberger</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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